OUR PROGRAMS
STEM and PROGENITOR CELL PROGRAM
Clinical Candidate, Dilanubicel (Clinical Stage)
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Stem and progenitor cell therapy: derived from cord blood and intended for use as a non-engrafting adjuvant cell therapy with chemotherapy to enhance remission rates and improve overall survival in AML patients
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Universal donor therapy: any dose for any patient; no matching required
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Off-the-shelf fixed doses: fully released and ready for infusion on the patient's timeline
Dilanubicel Key Characteristics
Dilanubicel is positioned for de novo and treatment related Acute Myeloid Leukemia patients and not limited to specific sub-populations
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Clinically convenient: easily added to standard of care regimens as determined by the treating physician
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Easily administered: simple infusion at the bedside over minutes
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Generally well-tolerated: >300 patients infused over multiple trials and indications
About Acute Myeloid Leukemia (AML)
Achieving remission with initial treatment is critical to survival and quality of life
DEVERRA IS ADDRESSING THE UNMET NEED WITH DILANUBICEL
Dilanubicel is a novel, non-engrafting adjuvant cell therpay to enhance remission rates and improve survival and quality of life
82% are ≥ 6o years
at diagnosis
> 50,000 (global) / 20,240 (US)
new AML patients
per year by 2025
Significant toxicity with intensive chemotherapy limits use in older patients
5-year overall survival is < 30%
AML is a complex and difficult to treat blood cancer with poor long-term survival
UNMODIFIED NK CELLS PROGRAM
Deverra’s Approach to NK Cell Generation Overcomes Common Challenges for a Differentiated Position Among Cell and Gene Therapy Companies
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Can be used as an allogeneic therapy without HLA matching to the patient
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Have a proven safety record as a cell therapy, generating no graft vs host disease or cytokine release syndrome
Advantages of NK Cells as Immunotherapy
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Can be generated ahead of time and crypopreserved to be ready for immediate off-the-shelf use for any patient
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Repeat dosing regimens possible
Natural Killer Cells (Clinical Stage), Myeloid Cells (Preclinical)
About Immune Effector Cells
NK CELLS ARE:
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A type of white blood cell (lymphocyte) of the immune system
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The body's first line of defense against cells transformed by cancer or viarlly infected cells
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Known for their ability to directly kill their target (cancer cells/virally infected cells) without the need for prior education or prior activation
MYELOID CELLS ARE:
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A family of white blood cell subtypes that includes monocytes, macrophages, and dendritic cells
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Recruited to sites of tissue damage or infection where they phagocystise (eat) abnormal cells, bacteria, and other pathogens
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Able to activate and educate other immune cells by releasing cytokines and presenting parts of the pathogens they have easten (antigens)
Deverra's NK cell therapy is currently under evaluation in two phase one clinical trials in patients with 1) Covid-19 and 2) relapsed/refractory AML or MDS
MODIFIED IMMUNE EFFECTOR CELL PROGRAM
Deverra is developing engineered NK and myeloid cells for the treatment of hematologic malignancies and solid tumors. These engineered cells can be used alone or importantly in combination to take full advantage of immune cell function and potency not only of the infused cells but of the host immune system as well.
In addition to more traditional viral gene delivery systems, Deverra is investigating novel non-viral gene delivery systems
Engineered NK and Myeloid Cells (preclinical/IND-enabling)
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NK cells are highly potent lymphocytes that target cancer through multiple broadly expressed activating ligands and they can be used allogeneically without the risk of graft versus host disease (GvHD) that is associated with T cell therapies
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Engineering is a way of enhancing these cells to specifically identify and more potently kill their targets
Why engineer immune effector cells?
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Marcrophages form an indispensable part of the immune response, performing a host of tasks crucial for the regulation of the immune system. Not only are they professional antigen-presenting cells, but they also actively participate in the immune response through phagosytosis and clearance of cellular debris
